Why Supplement Cycling Might Be the Key to Long-Term Health
- botchey
- Jul 2
- 2 min read
Most of us grew up with some form of daily vitamins, whether it was a chalky chewable, sugar-dusted, cartoon-shaped gummies. It’s common knowledge that essential vitamins like Vitamin D or a B-Complex can be part of a healthy daily routine. But what happens when we venture into the world of advanced supplements like spermidine, NAD, or high-dose antioxidants?
This is where the concept of supplement cycling becomes not only useful but essential.

What Is Supplement Cycling?
Supplement cycling is the practice of taking certain supplements for a set period (e.g. 12 weeks), followed by a deliberate break. This “on and off” approach helps the body maintain balance while still reaping the benefits of nutritional support.
According to Dr. Elizabeth Yurth of the Boulder Longevity Institute, cycling is particularly important for more aggressive or niche supplements. While daily multivitamins might be safe to take consistently, others can cause unintended effects if used without pause.

Why Your Body Needs a Break
The body is an incredibly complex network of systems, pathways, and messengers. Piling on supplements, especially over long periods, can disrupt this balance, leading to:
Physical overload: Organs like the liver, which filter out excess compounds, can become strained.
Financial cost: Supplements aren’t cheap, and overuse can be a drain on your wallet.
Mental stress: Managing dosages, interactions, and timing can add unnecessary anxiety to your routine.
When Good Supplements Go Too Far
Let’s look at antioxidants. They’re touted everywhere as the ultimate fix for oxidative stress. But not all oxidative stress is bad, some is essential for healthy cellular adaptation and repair. Flooding the system with antioxidants continuously can dull these natural responses, leading to imbalances.
Similarly, 5-HTP is often used to boost sleep and mood by increasing serotonin and melatonin. Sounds great, until you take it too long. Over time, it may force tryptophan down an alternate pathway, potentially leading to neurological issues or even worsening the symptoms it was meant to treat.
The Role of Homeostasis
At the core of supplement cycling is a simple principle: balance. Known medically as homeostasis, it’s the body’s way of staying in harmony. Without it, even the best supplements can lead us astray.
By cycling, we give our systems a chance to rest, reset, and avoid adaptation plateaus. Just like in training, doing the same thing too often leads to diminishing returns. Variety challenges the body to keep growing and responding effectively.

Practical Takeaway
If you’re sticking to basics, like a daily multivitamin or Vitamin D, you’re likely fine to stay the course. But if you're exploring more advanced supplements, consider a 12-weeks-on, 12-weeks-off approach. This gives your body time to recalibrate and maintain its natural rhythm.
And of course, always consult a professional before diving into complex supplement regimens. Expert guidance ensures you’re not just guessing but making informed, safe choices.
Book a Consultation If you would like personalised advice on supplement cycling, get in touch: pa@drbotchey.com